Most accessible signals in gastric physiology are indirect — serum gastrin and pepsinogen ratios are mucosal surrogates, and intubation perturbs what it measures. The Heidelberg pH Capsule System gives you the dependent variable itself: luminal pH over time, in a conscious, ambulatory subject, with a standardized challenge you can repeat within and between subjects.
Two-point calibration at pH 1.0 and 7.0 anchors every measurement. The bicarbonate challenge is standardized in volume and concentration; reacidification time and time-to-onset are operationally defined and extracted directly from the tracing.
Two-point calibration at pH 1.0 and pH 7.0 against reference buffers.
The subject swallows the tethered capsule. Record fasting baseline pH, then deliver sequential sodium bicarbonate challenges.
Time the return to baseline acidity after each challenge. Reacidification interval, pattern, and how strongly the stomach restores its acidity, read directly from the tracing..
How research groups work with us.Equipment provision, protocol and calibration support, and methodological consultation for grant-funded and investigator-initiated studies.
System provided for the study duration, with calibration standards and capsules.
Help defining the challenge protocol and outcome measures for your design.
Reusable Medallion M1 reader; single-use capsules support sequential subjects across a study day.
Input on reproducibility, calibration, and tracing interpretation.